Dynamics of piezoceramics-based mass and force actuators for rotating machines

In the past decade, it has become more and more common to install active vibration control devices on rotating systems like grinding machines, tooling centers, industrial fans and drive shafts. In the present research, two innovative actuation concepts for such devices are evaluated. The first device is a force actuator based on piezoceramic fibers, which has a low power consumption and high dynamic range. The second device is a mass redistribution actuator based on two piezoelectric ultrasonic motors, which is smaller and faster than conventional electromagnetic devices. At the basis of the analysis are rotor dynamic finite element models including actuators, sensors and feedback controllers. In simulations and experiments with device one, feedback control and scheduled feedforward control are considered. It is shown experimentally that the unbalance response at a critical speed can be reduced by some 97%. In experiments with device two, the positioning speed is determined

NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis

In previous studies we have found that FcγRI determines chondrocyte death and matrix metalloproteinase (MMP)-mediated cartilage destruction during IFN-γ-regulated immune complex arthritis (ICA). Binding of immune complexes (ICs) to FcγRI leads to the prominent production of oxygen radicals. In the present study we investigated the contribution of NADPH-oxidase-driven oxygen radicals to cartilage destruction by using p47phox(-/- )mice lacking a functional NADPH oxidase complex. Induction of a passive ICA in the knee joints of p47phox(-/- )mice resulted in a significant elevation of joint inflammation at day 3 when compared with wild-type (WT) controls as studied by histology. However, when IFN-γ was overexpressed by injection of adenoviral IFN-γ in the knee joint before ICA induction, a similar influx of inflammatory cells was found at days 3 and 7, comprising mainly macrophages in both mouse strains. Proteoglycan depletion from the cartilage layers of the knee joints in both groups was similar at days 3 and 7. Aggrecan breakdown in cartilage caused by MMPs was further studied by immunolocalisation of MMP-mediated neoepitopes (VDIPEN). VDIPEN expression in the cartilage layers of arthritic knee joints was markedly lower (between 30 and 60%) in IFN-γ-stimulated arthritic p47phox(-/- )mice at day 7 than in WT controls, despite significant upregulation of mRNA levels of various MMPs such as MMP-3, MMP-9, MMP-12 and MMP-13 in synovia and MMP-13 in cartilage layers as measured with quantitative RT-PCR. The latter observation suggests that oxygen radicals are involved in the activation of latent MMPs. Chondrocyte death, determined as the percentage of empty lacunae in articular cartilage, ranged between 20 and 60% at day 3 and between 30 and 80% at day 7 in WT mice, and was completely blocked in p47phox(-/- )mice at both time points. FcγRI mRNA expression was significantly lower, and FcγRII and FcγRIII were higher, in p47phox(-/- )mice than in controls. NADPH-oxidase-driven oxygen radical production determines chondrocyte death and aggravates MMP-mediated cartilage destruction during IFN-γ-stimulated IC-mediated arthritis. Upregulation of FcγRI by oxygen radicals may contribute to cartilage destruction

Elan: a professional framework for multimodality research

Utilization of computer tools in linguistic research has gained importance with the maturation of media frameworks for the handling of digital audio and video. The increased use of these tools in gesture, sign language and multimodal interaction studies has led to stronger requirements on the flexibility, the efficiency and in particular the time accuracy of annotation tools. This paper describes the efforts made to make ELAN a tool that meets these requirements, with special attention to the developments in the area of time accuracy. In subsequent sections an overview will be given of other enhancements in the latest versions of ELAN, that make it a useful tool in multimodality research. 1

OntoELAN: An Ontology-based Linguistic Multimedia Annotator

Despite its scientific, political, and practical value, comprehensive information about human languages, in all their variety and complexity, is not readily obtainable and searchable. One reason is that many language data are collected as audio and video recordings which imposes a challenge to document indexing and retrieval. Annotation of multimedia data provides an opportunity for making the semantics explicit and facilitates the searching of multimedia documents. We have developed OntoELAN, an ontology-based linguistic multimedia annotator that features: (1) support for loading and displaying ontologies specified in OWL; (2) creation of a language profile, which allows a user to choose a subset of terms from an ontology and conveniently rename them if needed; (3) creation of ontological tiers, which can be annotated with profile terms and, therefore, corresponding ontological terms; and (4) saving annotations in the XML format as Multimedia Ontology class instances and, linked to them, class instances of other ontologies used in ontological tiers. To our best knowledge, OntoELAN is the first audio/video annotation tool in linguistic domain that provides support for ontology-based annotation.Comment: Appeared in the Proceedings of the IEEE Sixth International Symposium on Multimedia Software Engineering (IEEE-MSE'04), pp. 329-336, Miami, FL, USA, December, 200

Selective Elimination of Synovial Macrophages by Boron Neutron Capture Therapy Prevents Onset of Murine Experimental Arthritis

Selective delivery of boron-10 encapsulated in liposomes to synovial macrophages in knee joints of mice combined with neutron irradiation (boron neutron capture therapy: BNCT) almost completely prevents the onset of experimental arthritis.JRC.F.3-Energy securit